Analysis of alternative splicing and alternative transcriptional initiation

Computational Analysis of Alternative Splicing and Transcriptional Initiation Patterns

Role of Aberrant Alternative Splicing in Cancer

Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...

Automated classification of alternative splicing and transcriptional initiation and construction of visual database of classified patterns

MOTIVATION Large-scale detection and classification of alternative splicing and transcriptional initiation (ASTI) is the first step towards detailed studies of the functional implication and mechanisms of these phenomena. RESULTS We have developed an algorithm that classifies all observed units of ASTI into an extendable set of distinct types (e.g. cassette type) by converting a collection of...

An Algorithm for Classification of Alternative Splicing and Transcriptional Initiation and Its Genome-Wide Application

We developed an algorithm that classifies all observed units of alternative splicing and transcriptional initiation and termination (UASTs) into an extendable set of distinct elementary patterns, when a collection of alignments between genomic DNA sequences and a set of cDNA/EST sequences are provided. The algorithm first converts aligned exon-intron structures into bit arrays, extracts UASTs, ...

Bioinformatics analysis of alternative splicing

Over the past few years, the analysis of alternative splicing using bioinformatics has emerged as an important new field, and has significantly changed our view of genome function. One exciting front has been the analysis of microarray data to measure alternative splicing genome-wide. Pioneering studies of both human and mouse data have produced algorithms for discerning evidence of alternative...